ABSTRACT
Mitochondria are an essential component of multicellular life and play important roles in the health of the cells and the body. Mitochondria can produce energy by oxidative phosphorylation, mediate calcium and reactive oxygen signal transduction, and regulate cell apoptosis. Recent studies indicate that mitochondria continually change their shapes and distribution by fission and fusion, which are collectively termed mitochondrial dynamics. Mitochondrial dynamics play critical roles in maintaining mitochondrial function. This review focuses on the structure and biological functions of mitochondrial fission and fusion related proteins in mammal cells.
ABSTRACT
OBJECTIVE@#To analyze the forensic pathological characteristics of sudden death caused by pulmonary thromboembolism and the chronological transformation of thrombus and explore the assessment method of the causal relationship between previous trauma and the following fatal PTE episode.@*METHODS@#All the 23 cases reviewed here were collected from our institute files from the year of 1998 to 2008.@*RESULTS@#Trauma, surgery and braking etc. were all risky factors of PTE. Of these cases, 12 cases were caused by trauma, 21 cases were caused by surgery and 22 cases died in hospitals which were often happened one or two weeks after injury or one week's postoperative time. Of all the cases, 6 cases had single attack of thrombus and the rest 17 cases had the recurrence of thrombus. The number of the leg deep vein to be the embolic source was 16 cases which were often seen in the left leg.@*CONCLUSION@#It is important to confirm the embolic source, trauma, surgery and chronological events in determing the sudden death with PTE.
Subject(s)
Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Young Adult , Autopsy , Cause of Death , Death, Sudden/etiology , Expert Testimony , Forensic Pathology , Leg/blood supply , Pulmonary Artery/pathology , Pulmonary Embolism/pathology , Retrospective Studies , Risk Factors , Venous Thrombosis/pathology , Wounds and Injuries/complicationsABSTRACT
OBJECTIVE@#To analyze the pathological characteristics and the death reasons due to postpartum hemorrhage, and to help to deal with the obstetrical medical tangles.@*METHODS@#Thirty-two cases of death caused by postpartum hemorrhage encountered in our department since 1995 had been collected and retrospectively analyzed.@*RESULTS@#Death caused by postpartum hemorrhage could be divided into single factor and multi-factor, with 81.25% due to single factor, 12.50% multi-factor, and 6.25% unknown reason. The single factors included uterine atony, retained placenta, placenta increta, laceration of the lower genital tract, and coagulation defects. The multi-factor included a combination of two or more factors mentioned above.@*CONCLUSION@#The causes of death due to postpartum hemorrhage should be analyzed according to the clinical characteristics of the postpartum hemorrhage and the autopsy examination.
Subject(s)
Female , Humans , Pregnancy , Autopsy , Blood Coagulation Disorders/complications , Cause of Death , Forensic Pathology , Placenta, Retained , Postpartum Hemorrhage/etiology , Retrospective Studies , Uterine InertiaABSTRACT
OBJECTIVE@#To estimate the significance of myocardial collagen I in the early acute myocardial ischemia of human.@*METHODS@#The myocardial paraffin block had normal group, early myocardial ischemia group and myocardial infarction group. The myocardial collagen I was observed with immunohistochemical staining and analyzed by half-quantity.@*RESULTS@#The similar expression of collagen I was observed in the cytoplasm and nucleolus in two groups.@*CONCLUSION@#The collagen I appeared in the myocardium of early acute myocardial ischemia of human. It may be an important index for postmortem diagnosis of the early acute myocardial ischemia.
Subject(s)
Humans , Collagen Type I/metabolism , Death, Sudden, Cardiac , Forensic Pathology , Myocardial Ischemia/metabolism , Postmortem Changes , Time FactorsABSTRACT
OBJECTIVE@#To explore the methods for sex determination on head CT film.@*METHODS@#To establish the sex determination equations by binary regression analysis of cranial skeletal indices obtained on head CT film.@*RESULTS@#A single element equation by applying the index of the width of ansa capitis and a multi-element equation by applying multitude indices were established.@*CONCLUSION@#The equations for sex determination on head CT film were established.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Algorithms , Facial Bones/anatomy & histology , Forensic Anthropology , Head/diagnostic imaging , Logistic Models , ROC Curve , Sex Determination by Skeleton/methods , Tomography, X-Ray Computed/methods , Zygoma/anatomy & histologyABSTRACT
OBJECTIVE@#To explore a method of measuring intracranial hemorrhage to be applied in clinical forensic science.@*METHODS@#The accurace of the methods of Tada formula, Stereology and Software boundary to measure intracranial hemorrhage and their practicability were compared.@*RESULTS@#The measured results of Stereology and Software boundary are precise, but the irregularity haematoma volume measured by the method of Tada formula has a high error value.@*CONCLUSION@#The method of stereolgy is the best in measuring intracranial hemorrhage for clinical forensic science.